Toxicokinetic Tools for Decision Making Using New Approach Methodologies
Thursday, Jan. 11, 2024 | 9 a.m. – 4:00 p.m. (U.S. Pacific Time Zone)
Coastal Hearing Room, CalEPA Headquarters Building | 1001 I St. | Sacramento, CA 95814
The California EPA Office of Environmental Health Hazard Assessment (OEHHA) and Texas A&M Superfund Research Center explored the use of toxicokinetics in applying new approach methodologies to chemical assessments.
The workshop focused on read-across methods and high-throughput tests for accelerating the evaluation of chemicals that lack traditional assessments.
Speakers and panelists: Lauren Zeise (CalEPA OEHHA), Weihsueh Chiu (Texas A&M), Grace Patlewicz (U.S. EPA), Nicholas Ball (Dow Chemical), Ivan Rusyn (Texas A&M), Alistair Middleton (Unilever), John Wambaugh (U.S. EPA), Tracey Woodruff (UC-San Francisco), and Kannan Krishnan (CalEPA OEHHA)
Agenda
| Time (US Pacific) | Topic | Speaker(s) |
|---|---|---|
| 9:00–9:30 a.m. | Welcome and introductions | Lauren Zeise (CalEPA OEHHA) |
| 9:30–9:45 a.m. | Charge to the participants | Ivan Rusyn (Texas A&M University) |
| 9:45–10:15 a.m. | Overview of forward and reverse PK methods in risk assessment | Weihsueh Chiu (Texas A&M University) |
| 10:15–10:30 a.m. | BREAK | |
| 10:30–11:00 a.m. | Read-across assessment frameworks and their application for chemical evaluation | Grace Patlewicz (U.S. EPA, Research Triangle Park, NC) |
| 11:00–11:30 a.m. | Case studies of read-across decisions by the European Chemicals Agency that were impacted by toxicokinetic considerations | Nicholas Ball (Dow Chemical Company, Switzerland) |
| 11:30 a.m.–12:30 p.m. | Moderated panel discussion [Grace Patlewicz, Nicholas Ball, and Tracey Woodruff (UC-San Francisco)] | Moderated by Ivan Rusyn (Texas A&M University) |
| 12:30–1:30 p.m. | LUNCH | |
| 1:30–2:00 p.m. | A toolbox for NAMs-based decision making based on the physiologically based kinetic (PBK) models to estimate systemic Cmax levels in humans at various exposure scenarios | Alistair Middleton (Unilever, UK) |
| 2:00–2:30 p.m. | Translating NAMs PODs to human oral equivalent doses using IVIVE – experimental and computational methods for setting toxicokinetic parameters | John Wambaugh (U.S. EPA, Research Triangle Park, NC) |
| 2:30–2:45 p.m. | BREAK | |
| 2:45–3:45 p.m. | Moderated panel discussion [Alistair Middleton, John Wambaugh, and Tracey Woodruff] | Moderated by Weihsueh Chiu (Texas A&M University) |
| 3:45–4:00 p.m. | Closing remarks | Kannan Krishnan (CalEPA OEHHA) |
For more information, email tamusuperfund@tamu.edu.