CalEPA OEHHA Event | Jan. 2024

Toxicokinetic Tools for Decision Making Using New Approach Methodologies

Thursday, Jan. 11, 2024 | 9 a.m. – 4:00 p.m. (U.S. Pacific Time Zone)
Coastal Hearing Room, CalEPA Headquarters Building | 1001 I St. | Sacramento, CA 95814

The California EPA Office of Environmental Health Hazard Assessment (OEHHA) and Texas A&M Superfund Research Center explored the use of toxicokinetics in applying new approach methodologies to chemical assessments. 

The workshop focused on read-across methods and high-throughput tests for accelerating the evaluation of chemicals that lack traditional assessments. 

Speakers and panelists: Lauren Zeise (CalEPA OEHHA), Weihsueh Chiu (Texas A&M), Grace Patlewicz (U.S. EPA), Nicholas Ball (Dow Chemical), Ivan Rusyn (Texas A&M), Alistair Middleton (Unilever), John Wambaugh (U.S. EPA), Tracey Woodruff (UC-San Francisco), and Kannan Krishnan (CalEPA OEHHA)


(US Pacific)
9:00–9:30 a.m.Welcome and introductionsLauren Zeise
9:30–9:45 a.m.Charge to the participantsIvan Rusyn
(Texas A&M University)
9:45–10:15 a.m.Overview of forward and reverse PK methods in risk assessmentWeihsueh Chiu
(Texas A&M University)
10:15–10:30 a.m.BREAK
10:30–11:00 a.m.Read-across assessment frameworks and their application for chemical evaluationGrace Patlewicz
(U.S. EPA, Research Triangle Park, NC)
11:00–11:30 a.m.Case studies of read-across decisions by the European Chemicals Agency that were impacted by toxicokinetic considerationsNicholas Ball
(Dow Chemical Company, Switzerland)
11:30 a.m.–12:30 p.m.Moderated panel discussion [Grace Patlewicz, Nicholas Ball, and Tracey Woodruff (UC-San Francisco)]Moderated by Ivan Rusyn
(Texas A&M University)
12:30–1:30 p.m.LUNCH
1:30–2:00 p.m.A toolbox for NAMs-based decision making based on the physiologically based kinetic (PBK) models to estimate systemic Cmax levels in humans at various exposure scenariosAlistair Middleton
(Unilever, UK)
2:00–2:30 p.m.Translating NAMs PODs to human oral equivalent doses using IVIVE – experimental and computational methods for setting toxicokinetic parametersJohn Wambaugh
(U.S. EPA, Research Triangle Park, NC)
2:30–2:45 p.m.BREAK
2:45–3:45 p.m.Moderated panel discussion [Alistair Middleton, John Wambaugh, and Tracey Woodruff]Moderated
by Weihsueh Chiu
(Texas A&M University)
3:45–4:00 p.m.Closing remarksKannan Krishnan