New Tools and Approaches to Support Decision-Making in Inhalation Toxicology
Thursday, May 23, 2024 | 9 a.m. – 4:00 p.m. (US Pacific Time Zone)
Coastal Hearing Room | CalEPA Headquarters Building | 1001 I St. | Sacramento, CA 95814
Join the California EPA Office of Environmental Health Hazard Assessment (OEHHA) and the Texas A&M Superfund Research Center to explore the use of new approach methodologies in inhalation toxicology and air toxics risk assessment.
The workshop will focus on read-across methods and high-throughput tests to support decision-making for air toxics that lack traditional assessments.
Speakers and panelists: Lauren Zeise (OEHHA), Ivan Rusyn (Texas A&M), Kannan Krishnan (OEHHA), David Dorman (NCSU), Allison Phillips (US EPA), Sylvia Escher (FITEM, Hannover), Jennifer Sass (NRDC), James Armitage (AES Inc., Ottawa), Xiaoqing Chang (Inotiv, supporting NICEATM), Weihsueh Chiu (Texas A&M), and Anatoly Soshilov (OEHHA)
Agenda
| Time (US Pacific) | Topic | Speaker(s) |
|---|---|---|
| 9:00–9:10 a.m. | Welcome and introductions | Lauren Zeise (OEHHA) |
| 9:10–9:20 a.m. | Workshop overview and charge to the participants | Ivan Rusyn (Texas A&M University) |
| 9:20–9:40 a.m. | Assessing health risks of air toxics in California: Overview and needs | Kannan Krishnan (OEHHA) |
| 9:40–10:10 a.m. | Challenges of inhalation toxicology and where might NAMs fit in? | David Dorman (North Carolina State University) |
| 10:15–10:30 a.m. | BREAK | |
| 10:30–11:00 a.m. | Use of read-across to develop provisional health guidance values | Allison Phillips (US EPA) |
| 11:00–11:30 a.m. | Tiered testing and assessment strategy using NAMs data to inform decision-making on inhalation exposures | Sylvia Escher (Fraunhofer Institute for Toxicology and Experimental Medicine) |
| 11:30 a.m.–12:30 p.m. | Moderated panel discussion [David Dorman, Allison Phillips, Sylvia Escher, and Jennifer Sass (NRDC)] | Moderated by Ivan Rusyn (Texas A&M University) |
| 12:30–1:30 p.m. | LUNCH | |
| 1:30–2:00 p.m. | Dosimetry considerations for in vitro assays of volatile chemicals | James Armitage (AES Inc.) |
| 2:00–2:30 p.m. | IVIVE approaches to studies of inhalation toxicants | Xiaoqing Chang (Inotiv, supporting NICEATM) |
| 2:30–2:45 p.m. | BREAK | |
| 2:45–3:45 p.m. | Moderated panel discussion [James Armitage, Xiaoqing Chang, and Jennifer Sass (NRDC)] | Moderated by Weihsueh Chiu (Texas A&M University) |
| 3:45–4:00 p.m. | Closing remarks | Anatoly Soshilov (OEHHA) |