Wednesday, Nov. 3, 2021 | 1:00–3:00 p.m. (Central US Time)
Caroline Ring—US Environmental Protection Agency
Zoom Details: Will be emailed to registrants on the morning of the session
PLACING TOXICOLOGY DATA IN THE CONTEXT OF EXPOSURE
“The dose makes the poison” – in other words, risk is a function of both hazard and exposure.
New approach methodologies (NAMs) for hazards, such as in vitro high-throughput screening assays, can rapidly estimate hazards for thousands of chemicals. But those thousands of chemicals may have little or no measured exposure data.
How can we estimate exposures – and meaningfully compare them to in vitro hazard data?
This session will present an overview of exposure NAMs in US EPA’s ExpoCast project to inform exposure estimation from source to receptor, and a discussion of the high-throughput toxicokinetics approach used to place in vitro HTS hazard data in the context of in vivo exposures.
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